OK, no evidence the authors took into account the mixed-effect model used to test for differences between groups over time in their power calculations, but can't you/someone run the more complex and appropriate power calculations to check how far from reasonable the sample size actually is considering the statistical model used?

How do we know that ECT's benefits aren't from anesthesia?

ECT seemed to get a lot better when they started anesthetizing people for the procedure, which is exactly what you'd expect if anesthesia was the active thing here.

Fantastic article Thomas, we have also been debating this one in our circles and your piece sums up a lot of our thoughts but you have made them explicit. Thank you!

The study amply proves the power of expectancy. If people thought they got ketamine (but actually received placebo) they improved 42%. But, if they thought they got placebo, (but actually got ketamine), they improved 25%. There was no difference between placebo and ketamine efficacy in the people who got placebo. (Graph B). So, people's beliefs had a profound effect on their improvement, and the power of belief over-rode the impact of the chemical that was put in their bodies.

OK, no evidence the authors took into account the mixed-effect model used to test for differences between groups over time in their power calculations, but can't you/someone run the more complex and appropriate power calculations to check how far from reasonable the sample size actually is considering the statistical model used?

One issue worth noting:

ECT is ALSO done under anesthesia.

How do we know that ECT's benefits aren't from anesthesia?

ECT seemed to get a lot better when they started anesthetizing people for the procedure, which is exactly what you'd expect if anesthesia was the active thing here.

Nice discussion!

Fantastic article Thomas, we have also been debating this one in our circles and your piece sums up a lot of our thoughts but you have made them explicit. Thank you!

The study amply proves the power of expectancy. If people thought they got ketamine (but actually received placebo) they improved 42%. But, if they thought they got placebo, (but actually got ketamine), they improved 25%. There was no difference between placebo and ketamine efficacy in the people who got placebo. (Graph B). So, people's beliefs had a profound effect on their improvement, and the power of belief over-rode the impact of the chemical that was put in their bodies.

deletedNov 1, 2023Comment deleted