I also think nosology is an obstacle here. For years clinicians have noted a subtype of paranoid psychotic disorders in perimenopausal females, call it paraphrenia, involutional psycjosis etc, without prominent disorganization and good response to low dose AP. It was always this population rather than the SCZ population writ large, even including females with more typical onset, in which Estrogens stood a good chance of being useful.
I also think nosology is an obstacle here. For years clinicians have noted a subtype of paranoid psychotic disorders in perimenopausal females, call it paraphrenia, involutional psycjosis etc, without prominent disorganization and good response to low dose AP. It was always this population rather than the SCZ population writ large, even including females with more typical onset, in which Estrogens stood a good chance of being useful.
Interesting. I wasn't aware of this - perhaps these terms have fallen out of fashion.
I have an old copy of DSMII on my shelf. Paraphrenia isn’t in there but the involutional disorders are. https://www.cambridge.org/core/journals/psychological-medicine/article/abs/phenomenology-demography-and-diagnosis-in-late-paraphrenia/58112D3BD63CF4AD5184C5661EAAFFD5
Thanks for sharing this Rob Howard paper - but late paraphrenia is something completely different right?
I don’t think completely different. The usage of terms hasn’t been stable.
Would be curious to ask Rob about this.