In the future, psychiatrists may thus be able to use quantitatively analysed brain scans and other biomarkers as well as their own clinical judgement to stratify patients in terms of clinically meaningful outcomes. This would allow psychiatrists to tailor the form of treatment to the needs of each individual patient.
I assume that you are excluding functional MRI from your discussion? As a chemistry who used multinuclear NMR to characterize individual Molecules, it would seem that it would get you a lot closer to the biochemistry- physiology of individual brain structures and neurons. Is it be ause you. Can't do multinuclear fMRI on brains of living people at sufficient resolution (geometric and chemical shift)?
I think resting state fMRI is likely to have very small effects between groups, as per the Nature paper I cited. Task based fMRI might have bigger effects but probably difficult to translate into clinical settings.
I assume multinuclear NMR is the same as Magnetic Resonance Spectroscopy? This is a method I know less about. I gather that biologically relevant molecules (like glutamate and GABA) can be quantified but the spatial resolution is poor (ie the voxel in which these molecules are measured is so big that it's difficult to interpret how they relate to underlying brain function). It's a neuroimaging technique that has certainly been used in schizophrenia research but I can't see immediate clinical applications.
Deepak Sarpal has wonderful work from AJP .... https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2015.14121571
Interesting, but still not good enough for clinical utility...yet!
I agree. Also that is from 7 years ago. And we do have and fda approval on snt
I assume that you are excluding functional MRI from your discussion? As a chemistry who used multinuclear NMR to characterize individual Molecules, it would seem that it would get you a lot closer to the biochemistry- physiology of individual brain structures and neurons. Is it be ause you. Can't do multinuclear fMRI on brains of living people at sufficient resolution (geometric and chemical shift)?
I think resting state fMRI is likely to have very small effects between groups, as per the Nature paper I cited. Task based fMRI might have bigger effects but probably difficult to translate into clinical settings.
I assume multinuclear NMR is the same as Magnetic Resonance Spectroscopy? This is a method I know less about. I gather that biologically relevant molecules (like glutamate and GABA) can be quantified but the spatial resolution is poor (ie the voxel in which these molecules are measured is so big that it's difficult to interpret how they relate to underlying brain function). It's a neuroimaging technique that has certainly been used in schizophrenia research but I can't see immediate clinical applications.